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Trimethylglycine is an active metabolite of choline and a component of beetroot [1].  One of the main mechanisms of betaine is that it acts as a powerful methylator alongside folate, B6 and B12.  Some studies have shown that TMG supplementation will support the reduction of homocysteine levels into methionine.  Did you know that heart disease is the No. 1 killer in the U.S., killing more people than cancer, infectious diseases, and homicides combined [2]. According to a study in the European Journal of Clinical Investigation, 40% of stroke victims have elevated homocysteine compared to only 6% of controls. TMG may also increase the bodily levels of SAMe or active folate molecules and then those two can go on to donate to methyl groups in other parts of the body.  Interestingly enough, there are scientists investigating whether TMG can protect cells from stress [3].  The takeaway, TMG supports whole body methylation and supports heart health.

Plus there’s more……..TMG when used in mineral balancing (because we are all about HTMA – Hair Tissue Mineral Analysis) will support detoxification in the body of heavy metals, especially mercury and copper.  You can get TMG from foods, mostly grains, leafy greens (spinach), and beets; but it is also particularly abundant in Goji berries (plus did you know that these are the only berries that help to support HgH levels) which have been used for centuries in Chinese culture with multiple reported benefits.


Yep, you guessed it, TMG is great for exercise support too.  It has been linked to increased power output, and looks to benefit endurance volume.  Why?  Well, it has been toted for increasing Nitric Oxide production which widens the blood vessels and ultimately saturates the muscles with blood during short-term exercise.  Most support has been tested between 0.5-6g/day, however, recommendations are made that 1.25g twice per day for exercise support is optimal, although studies are lacking.   

[1] https://examine.com/supplements/trimethylglycine

[2] https://www.lifeextension.com/magazine/1997/7/cover

[3] https://selfhacked.com/blog/tmg-health-benefits/


Lisa Square
Vykon Supplements founded by Lisa Pitel-Killah, Hair Mineral Analysis Expert & Educator, Board-Certified Holistic Health Practitioner, Functional Diagnostic Practitioner, and multi-time Kettlebell Sport World Champion.  Her animal study includes Holistic Carnivore and Equine Nutritionist and advanced Animal HTMA (Hair Tissue Mineral Analysis). Lisa is the host of the Human Optimization podcast and the co-host of the annual HTMA Virtual Summit, bringing mineral education to the masses.  The science of HTMA can identify exactly what your body, or your animal’s body, needs to thrive.  Customize, simplify, and revitalize life with Vykon.


Sue’s background includes being a two sport athlete in University and a member of Ontario Field Hockey team. She completed her CIS eligibility in College for photojournalism following 25 years as a photojournalist. Supporting two daughters through competitive hockey, Sue discovered her passion for Holistic Nutrition and returned to study at the Institute of Holistic Nutrition, graduating with her Certified Nutrition Practitioner designation. She has a strong passion for supporting people through chronic stress. Sue enjoys time on the water, has her Level 1 SUP certification and recently started racing.


Kailan spent her youth on her family farm; from a young age she developed an interest in how the mental and physical wellness of animals can impact their bonding and performance. After improving the health of her equine companions, she has had some pivotal moments resulting in multiple national championship titles. Her inherent passion for health coupled with her degree in engineering has led her on this journey to help humans and animals alike realize the benefits of optimized health.  

Kailan’s goal is to enlighten others to the resources available, aid in resolving root cause of barriers and breakdown misconceptions surrounding poor behavioural patterns.


Yielding over a decade of professionalism in design and entrepreneurship, Grace is in charge of the many multimedia projects at Vykon. With an Advanced Diploma in Graphic Design, her artistic eye and a flair for creativity brings a unique touch to every project she undertakes. When she’s not working, Grace enjoys trying new recipes, watching movies and spending an afternoon in an art gallery.